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Current and Recent NCI and Trans-NIH Initiatives (R01,R21)
Initiatives that are active or have expired within the last 3 months (and associated notices)
 
2024 Active  Requests for Applications (RFA's)
RFA No. and Title Status - Expiration
CA24-012 Revision Applications for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (R01 Clinical Trial Optional)ACTIVE - OCT 02, 2024
 
2024 Active  Trans-NIH Requests for Applications (RFA's)
RFA No. and Title Status - Expiration
AG24-025 Leveraging Social Networks to Promote Widespread Individual Behavior Change (R01 Clinical Trial Optional)EXPIRED - NOV 04, 2023
HD24-007 Understanding and Mitigating Health Disparities experienced by People with Disabilities caused by Ableism (R01 Clinical Trial Optional)EXPIRED - NOV 30, 2023
NS24-021 HEAL Initiative: Understanding Individual Differences in Human Pain Conditions (R01 - Clinical Trial Optional)ACTIVE - FEB 07, 2025
 
2024 Active  Program Announcements (PAs)
PA No. and Title Status - Expiration
PAR24-047 Revision Applications for Validation of Biomarker Assays Developed Through NIH-Supported Research Grants (R01 Clinical Trial Not Allowed)ACTIVE - OCT 14, 2026
PAR24-039 Exploratory Grant Award to Promote Workforce Diversity in Basic Cancer Research (R21 Clinical Trial Not Allowed)ACTIVE - NOV 18, 2026
 
2024 Active  Trans-NIH Program Announcements (PAs)
PA No. and Title Status - Expiration
PAR24-077 Addressing Health and Health Care Disparities among Sexual and Gender Minority Populations (R01 - Clinical Trials Optional)ACTIVE - JAN 08, 2027
 
 
 
 
 
2023 Active  Requests for Applications (RFA's)
RFA No. and Title Status - Expiration
CA23-014 Development of Innovative Informatics Methods and Algorithms for Cancer Research and Management (R21 Clinical Trial Optional)EXPIRED - NOV 18, 2023
 
2023 Active  Trans-NIH Requests for Applications (RFA's)
RFA No. and Title Status - Expiration
HG23-033 Advancing Genomic Medicine Research (R21 Clinical Trial Optional)ACTIVE - FEB 12, 2025
HG23-032 Advancing Genomic Medicine Research (R01 Clinical Trial Optional)ACTIVE - FEB 12, 2025
HG23-017 Investigator-Initiated Research in Genomics and Health Equity (R01 Clinical Trial Optional)ACTIVE - JUL 09, 2025
OD23-017 Tobacco Regulatory Science (R01 Clinical Trial Optional)ACTIVE - MAY 05, 2025
OD23-014 Understanding Chronic Conditions Understudied Among Women (R01 Clinical Trial Optional)ACTIVE - JUN 21, 2024
OD23-013 Understanding Chronic Conditions Understudied Among Women (R21 Clinical Trial Optional)ACTIVE - JUN 21, 2024
 
2023 Active  Program Announcements (PAs)
PA No. and Title Status - Expiration
PAR23-292 Improving Care and Outcomes for Cancer Survivors from Sexual and Gender Minority (SGM) Populations (R01 Clinical Trial Optional)ACTIVE - JAN 08, 2027
PAR23-281 Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01 Clinical Trial Not Allowed)ACTIVE - SEP 08, 2026
PAR23-280 Mechanisms that Impact Cancer Risk with Use of Incretin Mimetics (R21 Clinical Trial Not Allowed)ACTIVE - JAN 08, 2027
PAR23-279 Mechanisms that Impact Cancer Risk with Use of Incretin Mimetics (R01 Clinical Trial Optional)ACTIVE - JAN 08, 2027
PAR23-273 Understanding Expectancies in Cancer Symptom Management (R01 Clinical Trial Required)ACTIVE - MAY 08, 2026
PAR23-264 Assay development and screening for discovery of chemical probes, drugs or immunomodulators (R01 Clinical Trial Not Allowed)ACTIVE - SEP 08, 2026
PAR23-259 Academic-Industrial Partnerships (AIP) to Translate and Validate In Vivo Imaging Systems (R01 Clinical Trial Optional)ACTIVE - JAN 08, 2027
PAR23-255 Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R21 Clinical Trials Not Allowed)ACTIVE - SEP 08, 2026
PAR23-254 Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R01 Clinical Trial Not Allowed)ACTIVE - SEP 08, 2026
PAR23-246 Innovative Research in Cancer Nanotechnology (IRCN; R01 Clinical Trial Not Allowed)ACTIVE - MAY 05, 2026
PAR23-244 Population Approaches to Reducing Alcohol-related Cancer Risk (R01 Clinical Trial Optional)ACTIVE - JAN 08, 2027
PAR23-155 Understanding Expectancies in Cancer Symptom Management (R01 Clinical Trial Required)ACTIVE - MAY 08, 2026
PAR23-153 Impacts of climate change across the cancer control continuum (R01 Clinical Trial Optional)ACTIVE - MAY 08, 2026
PAR23-152 Impacts of climate change across the cancer control continuum (R21 Clinical Trial Optional)ACTIVE - MAY 08, 2026
PAR23-088 Revision Applications for Validation of Biomarker Assays Developed Through NIH-Supported Research Grants (R01 Clinical Trial Not Allowed)EXPIRED - OCT 28, 2023
PAR23-056 Co-infection and Cancer (R21 Clinical Trial Not Allowed)ACTIVE - NOV 17, 2025
PAR23-055 Co-infection and Cancer (R01 Clinical Trial Not Allowed)ACTIVE - NOV 06, 2025
 
2023 Active  Trans-NIH Program Announcements (PAs)
PA No. and Title Status - Expiration
PAR23-318 Mobile Health: Technology and Outcomes in Low and Middle Income Countries (R21/R33 - Clinical Trial Optional)ACTIVE - MAR 21, 2026
PAR23-309 Health and Health Care Disparities Among Persons Living with Disabilities (R01 - Clinical Trials Optional)ACTIVE - NOV 06, 2026
PAR23-303 Unveiling Health and Healthcare Disparities in Non-Communicable and Chronic Diseases in Latin America: Setting the Stage for Better Health Outcomes Across the Hemisphere (R01 - Clinical Trials Not Allowed)ACTIVE - JAN 07, 2027
PAR23-299 Intervention Research to Improve Native American Health (R21 Clinical Trials Optional)ACTIVE - JAN 08, 2027
PAR23-298 Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)ACTIVE - JAN 08, 2027
PAR23-294 Ethical, Legal and Social Implications (ELSI) Exploratory/Developmental Research Grant (R21 Clinical Trial Optional)ACTIVE - NOV 19, 2026
PAR23-293 Ethical, Legal and Social Implications (ELSI) Research (R01 Clinical Trial Optional)ACTIVE - NOV 19, 2026
PAR23-270 Screening, Brief Intervention and Referral to Treatment or Prevention (SBIRT/P) for alcohol, tobacco, and other drugs (ATOD) use and misuse in adult populations that experience health disparities (R01, Clinical Trial Required)ACTIVE - MAY 08, 2027
PAR23-191 HIV-associated Non-Communicable Diseases Research at Low- and Middle-Income Country Institutions (R21 Clinical Trial Optional)ACTIVE - DEC 09, 2025
PAR23-190 Interventions for Stigma Reduction to Improve HIV/AIDS Prevention, Treatment and Care in Low- and Middle- Income Countries (R01 - Clinical Trial Optional)ACTIVE - DEC 23, 2025
PAR23-170 Interventions to expand cancer screening and preventive services to ADVANCE health in populations that experience health disparities (R01, Clinical Trial Required)ACTIVE - JAN 08, 2027
 
 
 
 
 
2022 Active  Requests for Applications (RFA's)
RFA No. and Title Status - Expiration
CA22-057 Basic/Translational Research on Health Disparities in Underrepresented People Living with HIV (PLWH) and Cancer (R21 Clinical Trial Not Allowed)ACTIVE - DEC 16, 2023
CA22-056 Basic/Translational Research on Health Disparities in Underrepresented People Living with HIV (PLWH) and Cancer (R01 Clinical Trial Not Allowed)ACTIVE - DEC 16, 2023
CA22-050 NCI Cancer Moonshot Scholars Diversity Program (CMSDP) (R01 Clinical Trial Optional)ACTIVE - FEB 07, 2024
CA22-043 Advancing Adolescent Tobacco Cessation Intervention Research (R01 Clinical Trial Required)EXPIRED - OCT 17, 2023
CA22-027 Research to Understand and Address the Survivorship Needs of Individuals Living with Advanced Cancer (R01 Clinical Trial Optional)EXPIRED - SEP 30, 2023
 
2022 Active  Trans-NIH Requests for Applications (RFA's)
RFA No. and Title Status - Expiration
NS22-070 HEAL Initiative: Development and Validation of Non-Rodent Mammalian Models of Pain(R01 Clinical Trial Not Allowed)ACTIVE - MAR 07, 2024
NS22-034 HEAL Initiative: Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R01 Clinical Trial Not Allowed)ACTIVE - DEC 07, 2024
OD22-009 Transformative Research Award for the INCLUDE (Investigation of Co-occurring Conditions across the Lifespan to Understand Down syndrome) Project (R01 Clinical Trial Not Allowed)ACTIVE - JUL 02, 2024
OD22-007 INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Clinical Trial Readiness (R21 Clinical Trial Not Allowed)ACTIVE - JUL 02, 2024
 
2022 Active  Program Announcements (PAs)
PA No. and Title Status - Expiration
PAR22-243 Bioengineering Research Grants (BRG) (R01 Clinical Trial Optional)ACTIVE - SEP 08, 2025
PAR22-242 Bioengineering Research Grants (BRG) (R01 Clinical Trial Not Allowed)ACTIVE - SEP 08, 2025
PAR22-219 Biology of Bladder Cancer (R21 Clinical Trial Optional)ACTIVE - SEP 08, 2025
PAR22-218 Biology of Bladder Cancer (R01 Clinical Trial Optional)ACTIVE - SEP 08, 2025
PAR22-216 NCI Clinical and Translational Exploratory/Developmental Studies (R21 Clinical Trial Optional)ACTIVE - JUL 02, 2025
PAR22-199 Precision Approaches in Radiation Synthetic Combinations (PAIRS, R21 Clinical Trial Optional)ACTIVE - SEP 08, 2025
PAR22-198 Precision Approaches in Radiation Synthetic Combinations (PAIRS, R01 Clinical Trial Optional)ACTIVE - SEP 08, 2025
PAR22-165 Innovative Approaches to Studying Cancer Communication in the New Information Ecosystem (R21 Clinical Trial Optional)ACTIVE - SEP 08, 2025
PAR22-164 Innovative Approaches to Studying Cancer Communication in the New Information Ecosystem (R01 Clinical Trial Optional)ACTIVE - SEP 08, 2025
PAR22-140 Systematic Testing of Radionuclides in Preclinical Experiments (STRIPE) (R21 Clinical Trial Not Allowed)ACTIVE - MAY 08, 2025
PAR22-139 Systematic Testing of Radionuclides in Preclinical Experiments (STRIPE) (R01 Clinical Trial Not Allowed)ACTIVE - MAY 08, 2025
PAR22-131 Imaging, Biomarkers and Digital Pathomics for the Early Detection of Premetastatic Cancer and Precancerous Lesions Associated with Lethal Phenotypes (R01 Clinical Trial Optional)ACTIVE - SEP 08, 2025
PAR22-109 Dissemination and Implementation Research in Health (R21 Clinical Trial Optional)ACTIVE - MAY 08, 2025
PAR22-105 Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)ACTIVE - MAY 08, 2025
PAR22-099 Cancer Tissue Engineering Collaborative: Enabling Biomimetic Tissue-Engineered Technologies for Cancer Research (R01 Clinical Trial Optional)ACTIVE - MAY 08, 2025
PAR22-091 Exploratory/Developmental Bioengineering Research Grants (EBRG) (R21 Clinical Trial Optional)ACTIVE - JAN 08, 2025
PAR22-090 Exploratory/Developmental Bioengineering Research Grants (EBRG) (R21 Clinical Trial Not Allowed)ACTIVE - JAN 08, 2025
PAR22-086 Microbial-based Cancer Imaging and Therapy - Bugs as Drugs (R21 Clinical Trial Not Allowed)ACTIVE - MAY 08, 2025
PAR22-085 Microbial-based Cancer Imaging and Therapy - Bugs as Drugs (R01 Clinical Trial Not Allowed)ACTIVE - MAY 08, 2025
PAR22-084 Epidemiologic Research on Emerging Risk Factors and Liver Cancer Susceptibility (R21 Clinical Trial Not Allowed)ACTIVE - MAY 08, 2025
PAR22-083 Epidemiologic Research on Emerging Risk Factors and Liver Cancer Susceptibility (R01 Clinical Trial Not Allowed)ACTIVE - MAY 08, 2025
PAR22-071 Toward Translation of Nanotechnology Cancer Interventions (TTNCI) (R01 Clinical Trial Not Allowed)ACTIVE - NOV 18, 2024
PAR22-062 Modulating Human Microbiome Function to Enhance Immune Responses Against Cancer (R21 Clinical Trial Not Allowed)ACTIVE - JAN 08, 2025
PAR22-061 Modulating Human Microbiome Function to Enhance Immune Responses Against Cancer (R01 Clinical Trial Not Allowed)ACTIVE - JAN 08, 2025
 
2022 Active  Trans-NIH Program Announcements (PAs)
PA No. and Title Status - Expiration
PAR22-145 Leveraging Health Information Technology (Health IT) to Address and Reduce Health Care Disparities (R01 Clinical Trial Optional)ACTIVE - MAY 08, 2025
PAR22-127 Focused Technology Research and Development (R01 Clinical Trial Not Allowed)ACTIVE - MAY 08, 2025
PAR22-126 Technology Development Research for Establishing Feasibility and Proof of Concept (R21 - Clinical Trial Not Allowed)ACTIVE - MAY 08, 2025
PAR22-092 Health Care Models for Persons with Multiple Chronic Conditions from Populations that Experience Health Disparities: Advancing Health Care towards Health Equity (R01 - Clinical Trials Optional)ACTIVE - SEP 08, 2024
PAR22-072 Measures and Methods to Advance Research on Minority Health and Health Disparities-Related Constructs (R01 Clinical Trial Not Allowed)ACTIVE - MAY 08, 2024
PAR22-064 Patient-Clinician Relationship: Improving Health Outcomes in Populations that Experience Health Care Disparities (R01 Clinical Trial Optional)ACTIVE - JAN 08, 2025
 
 
 
 
 
2021 Active  Trans-NIH Requests for Applications (RFA's)
RFA No. and Title Status - Expiration
OD21-007 INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Exploratory/Developmental Research Grant Award (R21 Clinical Trial Not Allowed)ACTIVE - JUL 04, 2024
 
2021 Active  Program Announcements (PAs)
PA No. and Title Status - Expiration
PAR21-341 Exploratory Grants in Cancer Control (R21 Clinical Trial Optional)ACTIVE - OCT 09, 2024
PAR21-332 Mechanisms that Impact Cancer Risk after Bariatric Surgery (R21 Clinical Trial Not Allowed)ACTIVE - SEP 08, 2024
PAR21-331 Mechanisms that Impact Cancer Risk after Bariatric Surgery (R01 Clinical Trial Optional)ACTIVE - SEP 08, 2024
PAR21-329 Clinical Characterization of Cancer Therapy-induced Adverse Sequelae and Mechanism-based Interventional Strategies (R01 Clinical Trial Optional)ACTIVE - NOV 06, 2024
PAR21-323 Basic Research in Cancer Health Disparities (R21 Clinical Trial Not Allowed)ACTIVE - SEP 08, 2024
PAR21-322 Basic Research in Cancer Health Disparities (R01 Clinical Trial Not Allowed)ACTIVE - SEP 08, 2024
PAR21-294 Molecular Imaging of Inflammation in Cancer (R01 Clinical Trial Not Allowed)ACTIVE - JAN 08, 2025
PAR21-290 Integration of Imaging and Fluid-Based Tumor Monitoring in Cancer Therapy (R01 Clinical Trial Optional)ACTIVE - SEP 08, 2024
PAR21-206 Academic-Industrial Partnerships for Translation of Technologies for Diagnosis and Treatment (R01 - Clinical Trial Optional)ACTIVE - MAY 08, 2024
PAR21-190 Modular R01s in Cancer Control and Population Sciences (R01 Clinical Trial Optional)ACTIVE - MAR 08, 2024
PAR21-166 Academic-Industrial Partnerships for Translation of Technologies for Diagnosis and Treatment (R01 - Clinical Trial Not Allowed)ACTIVE - JAN 08, 2024
PAR21-061 Exploratory Grant Award to Promote Workforce Diversity in Basic Cancer Research (R21 Clinical Trial Not Allowed)EXPIRED - NOV 18, 2023
PAR21-035 Cancer Prevention and Control Clinical Trials Grant Program (R01 Clinical Trial Required)ACTIVE - JAN 08, 2024
PAR21-033 National Cancer Institute's Investigator-Initiated Early Phase Clinical Trials for Cancer Treatment and Diagnosis (R01 Clinical Trial Required)ACTIVE - JAN 08, 2024
 
2021 Active  Trans-NIH Program Announcements (PAs)
PA No. and Title Status - Expiration
PAR21-358 Risk and Protective Factors of Family Health and Family Level Interventions (R01 - Clinical Trial Optional)ACTIVE - MAY 08, 2025
PAR21-352 Research on Biopsychosocial Factors of Social Connectedness and Isolation on Health, Wellbeing, Illness, and Recovery (R01 Clinical Trial Required)ACTIVE - SEP 08, 2024
PAR21-350 Research on Biopsychosocial Factors of Social Connectedness and Isolation on Health, Wellbeing, Illness, and Recovery (R01 Clinical Trials Not Allowed)ACTIVE - JUN 22, 2024
PAR21-349 Research on Biopsychosocial Factors of Social Connectedness and Isolation on Health, Wellbeing, Illness, and Recovery (R01 Basic Experimental Studies with Humans Required)ACTIVE - JUN 22, 2024
PAR21-305 Time-Sensitive Obesity Policy and Program Evaluation (R01 Clinical Trial Not Allowed)ACTIVE - SEP 11, 2024
PAR21-275 The Role of Work in Health Disparities in the U.S. (R01 Clinical Trials Optional)ACTIVE - SEP 08, 2024
PAR21-253 Identification and Characterization of Bioactive Microbial Metabolites for Advancing Research on Microbe-Diet-Host Interactions (R01 Clinical Trial Not Allowed)EXPIRED - OCT 20, 2023
PAR21-069 Multidisciplinary Studies of HIV/AIDS and Aging (R21 Clinical Trial Optional)ACTIVE - JAN 08, 2024
PAR21-068 Multidisciplinary Studies of HIV/AIDS and Aging (R01 Clinical Trial Optional)ACTIVE - JAN 08, 2024
PAR21-039 Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Basic Experimental Studies with Humans Required)ACTIVE - DEC 29, 2023
PAR21-038 Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed)ACTIVE - DEC 29, 2023
 
 
 
 
 
2020 Active  Trans-NIH Program Announcements (PAs)
PA No. and Title Status - Expiration
PAR20-254 Ethical, Legal and Social Implications (ELSI) (Research R01 Clinical Trial Optional)EXPIRED - NOV 18, 2023
PAR20-179 Advancing Research to Develop Improved Measures and Methods for Understanding Multimorbidity (R01 Clinical Trial Optional)ACTIVE - JAN 08, 2024
PA20-185 NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)ACTIVE - MAY 08, 2024