The System for Award Management (SAM) is a website that consolidates Federal procurement systems and the Catalog of Federal Domestic Assistance (CFDA). Currently CCR, FedReg, ORCA and EPLS have been migrated to SAM. You must be registered on SAM (within the Entity Management section), Grants.gov and eRA Commons to successfully submit an application to NIH.
Quoted from the NIH OER Glossary & Acronym List.
